MALAT1 and cancer: Overall, we identified (a) recurrent deleterious tumor-specific genetic variants, not previously associated with cancer or tumor aggressiveness, that may have potential diagnostic value due to the absence of the variants in normal tissue, (b) expressed fusion transcripts predominantly in ncRNAs, in particular MALAT1, and (c) potential prognostic genes associated with tumor aggressiveness that may play a pivotal role in cancer-related processes.