Previous evidences outlined the exosome-mediated secretion of lncRNAs and their detection in serum of cancer patients [16], thus we tested HCC derived cell lines for CASC9 and LUCAT1 expression in the intra and extracellular compartment, as well as in the exosomal fraction of cell culture supernatant. Here, CASC9 is linked to hepatocellular carcinoma.