BDNF and major depressive disorder: In contrast, it has been shown that repeated electroacupuncture at Baihui (GV-20) and Yintang (EX-HN3) increased glutamate, 5-hydroxytryptamine (5-HT), and the BDNF-related peptides, such as protein kinase C (PKC) and cyclic adenosine monophosphate response element binding protein, in the hippocampus and inhibited stress-induced depression [59].