Some CARs targeting tumor-specific antigens have been developed pre-clinically, including CARs targeting aberrantly glycosylated oncogenes, such as the Tn glycoform of MUC1 (54), and tumor-specific activating forms of integrin (55), and clinically, such as CARs targeting the tumor-specific transcriptional variants EGFRvIII in glioblastoma (56). This evidence concerns the gene MUC1 and neoplasm.