Murine TNF-α and murine IL-2 delivered by adenovirus could increase the efficacy of mesothelin-redirected CAR T cells in immunocompetent mice engrafted with highly immunosuppressive syngeneic LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) mice derived-pancreatic ductal adenocarcinoma (PDA) tumor, whereas multiple injections of anti-mesothelin-CAR T cell monotherapy failed to suppress tumor growth. Here, PDX1 is linked to neoplasm.