The nuclear receptor liver receptor homolog 1 (LRH-1) (also known as NR5A2) was recently found to have a regulatory role in hepatoma formation, since it was shown to upregulate mitochondrial ALT2/GPT2 and cytosolic AST1/GOT1 aminotransferase isoforms as well as glutaminase 2 (GLS2) (35). This evidence concerns the gene GPT2 and hepatocellular carcinoma.