PIK3CG and cardiac hypertrophy: PI3K activity is usually modulated by miR-133a, a miRNA involved in regulation of cardiac hypertrophy: increased levels of miR-133aare paralleled by PI3K inactivation (Horie et al., 2009; Abdellatif, 2010; Josse et al., 2014) or viceversa low levels of miR-133a link to PI3K activation.