PI3K is a major player for mediating cardiac glucose since it is a regulator of glucose transporters (Egert et al., 1997; Vlavcheski et al., 2018), it is involved in reduction of cardiac hypertrophy (Weeks et al., 2017), and it is stimulated by the MC5R after α-MSH activation in HEK293 cells (Rodrigues et al., 2009). This evidence concerns the gene PIK3CG and cardiac hypertrophy.