The same targets of CHMs and heart failure were extracted, and 15 targets were obtained (CA2, CACNA1C, CYP2D6, CYP1A2, CYP1A1, AR, CYP2C9, CYP3A4, XDH, ADORA1, ABCB1, CA1, ATP1A1, NR3C2, CACNA1D), indicating that the efficacy of CHM on heart failure maybe related to energy metabolism, regulation of calcium channel, regulation of water electrolyte balance and maintenance of homeostasis. This evidence concerns the gene CYP2D6 and heart failure.