SOD1 and amyotrophic lateral sclerosis: Mutations in various genes have been identified in ALS, including superoxide dismutase (SOD1) (Rosen et al., 1993) and TAR DNA-binding protein 43 (TDP43) (Arai et al., 2006; Neumann et al., 2006; Kabashi et al., 2008; Sreedharan et al., 2008; Van Deerlin et al., 2008).