SIRT1 and early-onset autosomal dominant Alzheimer disease: Increased expression of miR-34c and decreased expression of SIRT1 were detected in mice with age-associated memory impairment and APPPS-21 mice, which are a model of amyloid pathology linked to Alzheimer’s disease (AD) (Yamakuchi et al., 2008; Zovoilis et al., 2011).