Silent information regulator 1 activation using resveratrol and SIRT1 overexpression has been shown to reduce amyloid plaque formation and confer protective effects in diverse animal models of AD (Chen J. et al., 2005; Qin et al., 2006b; Kim et al., 2007; Karuppagounder et al., 2009; Vingtdeux et al., 2010). This evidence concerns the gene SIRT1 and Alzheimer disease.