Numerous systematic reviews discussing the beneficial functions of SIRT1 in AD have been published (Bonda et al., 2011; Donmez and Outeiro, 2013; Herskovits and Guarente, 2014; Ng et al., 2015); we therefore focus on recent findings on the role of SIRT1 and other sirtuins in AD in this section. This evidence concerns the gene SIRT1 and Alzheimer disease.