PKHD1 and autosomal recessive polycystic kidney disease: Significantly, in the Atmin-Pkhd1 double knockdown, cell adhesion levels were restored to control (98%, Fig. 5 K).Thus, a reduction in Atmin expression in the context of Pkhd1 knockdown can affect cellular proliferation and adhesion, signifying that changes in ATMIN expression may impact on cellular changes in ARPKD cystic epithelia.