Consistent with published work that showed that ARPKD cells exhibited increased adhesive properties and decreased polarised migration [18], a 2.74-fold increase in E-cadherin expression was observed in paediatric ARPKD kidneys compared to age-matched normal kidneys (Fig. 8A, B), signifying increased calcium-dependent cell-cell adhesion. The gene discussed is CDH1; the disease is autosomal recessive polycystic kidney disease.