Both radiotherapy and chemotherapy generate enormous intrinsic cellular stress as a result of damaged proteins and organelles, which induces autophagy to repair DNA and other cellular damage to restore cellular homeostasis.34 Moreover, autophagy inhibition increased the anti‐tumor effects of cetuximab.35 Also, EGFR‐targeted therapy increased the radiosensitivity of non‐small cell lung cancer by inhibiting autophagy.36 Interestingly, ERS also induces autophagy.20, 37 The regulation of radiosensitivity by autophagy is pleiotropic. Here, EGFR is linked to lung cancer.