EGFR activates several signaling pathways including extracellular signal‐regulated kinase (ERK) and protein kinase B (AKT), thereby promoting tumor cell proliferation, invasiveness, and survival.4 In addition, EGFR modulates tumor cell sensitivity to chemotherapy and radiotherapy.5, 6 However, the mechanisms determining radioresistance have not been fully established. The gene discussed is EGFR; the disease is neoplasm.