It has been noted that activated B cells produce interleukin-10 (IL-10) to inhibit autoimmunity by suppressing pathogenic T cells (Nakashima et al., 2010; Matsumoto et al., 2014) and HIF-1α deficiency results in an increased B1-like cell population which further causes autoimmunity (Kojima et al., 2002). The gene discussed is IL10; the disease is Autoimmunity.