ACE and heart failure: Underlying these low mortality rates, the use of neurohormonal antagonist drugs with prognostic benefit in heart failure was high in DANISH, with angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs), beta-blockers and mineralocorticoid receptor antagonists (MRAs) prescribed to 97%, 92% and 58% of patients respectively.