AEs leading to permanent treatment discontinuation included: malaise (n = 3); decreased appetite, diarrhea, abnormal liver function, and platelet count decreased (n = 2, each); and influenza, hypothyroidism, heart failure, mitral insufficiency, aortic dissection, nausea, duodenal perforation, gastrointestinal perforation, vomiting, hepatic disorder, rash, fever, aspartate aminotransferase increased, alanine aminotransferase increased, and neutrophil count decreased (n = 1, each). The gene discussed is GPT; the disease is Aortic dissection.