CD274 and neoplasm: Although two-thirds of the tumours with high densities of CD8+ TIL are associated with low infiltration by mature DCs, increased expression of inhibitory ligands (e.g., PD-L1 and PD-L2) and poor clinical outcome, the remaining third is highly enriched in TLSs, exhibit proliferating T cells and is associated with remarkably long PFS.77,92