ERBB2 and breast carcinoma: In breast cancer, the analysis of thousands of samples has found a strong association between high infiltration with CD8+ T cells or a Th1-gene signature and longer PFS and OS.95–100 Also, it has been suggested that this association is particularly strong in oestrogen receptor (ER) negative, HER-2 negative, as well as ER, progesterone receptor, HER-2 triple-negative breast cancers.99 In contrast, the infiltration with macrophages is associated with poor prognosis.101–103