ARG-1 upregulation in MDSCs leads not only to the inhibition of T cell functions, but also contributes to the production of extracellular matrix components and therefore tissue remodelling and tumour growth.69 The expression of ARG-1 by MDSCs can be induced by the Th2 cytokines IL-4, IL-10 and IL-13. The gene discussed is ARG1; the disease is neoplasm.