Elevated GATA3 we found in old animals may indicate enhanced activity by type 2 T-cell responses and allergy-like lung inflammation, since GATA3 is a transcription factor that is expressed by Th2 cells and Type 2 innate lymphoid cells, and promotes susceptibility to allergy-like inflammation associated with Th2 responses43–46. The gene discussed is GATA3; the disease is Allergy.