By immunoblot we detected increased DC-SIGN receptor expression by DCs induced by DPG3 relative to Pg381 and MFI or uninfected control (Fig. 1A,C), whereas blocking DC-SIGN with HIV-gp120 prior to infection reduced DPG3 (Mfa1) mediated-induction (Fig. 1B,C). The gene discussed is ITIH4; the disease is infection.