CXCR4 and neoplasm: Further, strain MFI (FimA+Mfa1−Pgingivalis) stimulates significant proliferation of CXCR4-expressing OSC (HN6, HN12) cells, but not those of noncancerous cells (oral keratinocytes, ARPE and MEF), which indicate that the interactions between FimA and CXCR4 play a primary role in promoting OSCCs tumor growth through the pAKT1-pFOXO1 dependent pathway(s).