While we are beginning to explore the therapeutic potential of targeted ROCK2 inhibition in the clinic, several reports demonstrated that KD025 effectively ameliorates animal models of autoimmunity, including collagen-induced arthritis17 and Mrl/lpr lupus19 in mice as well as reversed the pathology of the autoimmune-like syndrome, chronic graft-versus-host disease (cGVHD)18. The gene discussed is ROCK2; the disease is chronic graft versus host disease.