Importantly, recent studies demonstrated that targeted inhibition of ROCK2 down-regulates disease progression in MRL/lpr mouse model of lupus and effectively ameliorates clinical pathology in experimental chronic graft-versus-host disease (cGVHD) via inhibition of STAT3 phosphorylation accompanied by a reduced expression of IRF4, RORγt and Bcl6 transcription factors in splenic cells18,19. This evidence concerns the gene ROCK2 and chronic graft versus host disease.