However, in C/EBPβ-overexpressing cells, C/EBPβ recruitment at all Id3 regulatory regions examined was enriched as compared to pLXSN (Fig. 4E) suggesting that overexpression, which occurs in vivo with sarcopenia and cachexia28,29, can force C/EBPβ onto elements that are not normally occupied. The gene discussed is ID3; the disease is sarcopenia.