Some animal models with autophagic-lysosomal inhibition leading to increased p62/SQSTM1-levels show hypertension38 or cardiomyopathy39,40 further arguing in favor of a potential link between the accumulation of p62/SQSTM1-positive protein aggregates in cardiomyocytes with BD and hypertension or cardiomyocyte degeneration. The gene discussed is SQSTM1; the disease is Behcet disease.