APP and amyotrophic lateral sclerosis: The presence of APP in the BD-lesions also argues against impaired autophagy as primary cause of BD because other protein aggregation disorders that accumulate p62/SQSTM1-positive material can be driven by specific mutations of the accumulating protein such as mutations in the α-synuclein gene in Parkinson’s disease36 or in the TDP43 gene (TARDBP) in amyotrophic lateral sclerosis (ALS)37.