SQSTM1 and Behcet disease: Accordingly, the material that accumulates in BD-lesions and colocalized PAS-positivity, p62/SQSTM1, and ubiquitin appears to represent aggregates of sAPPη, sAPPδ373, or another N-terminal APP fragment with its C-terminus N-terminal to the η-secretase cleavage site (Fig. 1).