In the BD-lesions, the aggregated N-terminal APP fragments colocalize ubiquitin, p62/SQSTM1, and PAS-positivity, presumably indicative for the presence of glycosylated proteins such as APP that could be ubiquitinated and linked to p62/SQSTM1, as demonstrated by triple label immunofluorescence and by assessing subsequent sections. This evidence concerns the gene SQSTM1 and Behcet disease.