Antibodies against ubiquitin and ubiquilin were used to confirm an impaired proteasomal degradation, antibodies against abnormal τ-protein, α-synuclein, phosphorylated transactive response DNA-binding protein pTDP43, and Aβ/APP to identify potential target proteins that can theoretically accumulate in the cell, and antibodies against muscle-derived proteins to address the question whether BD-lesions represent a disorder of the cardiomuscular intermediary filaments. This evidence concerns the gene APP and Behcet disease.