It is generally recognized that pro-inflammatory cytokines, such as IL-12, IL-1β, and IL-6 are the major contributors promoting inflammatory environments suitable for conversion of Treg cells into different types of ex-Treg cells under conditions of varied immune disorders such as ocular infection43, helminth infection49, or autoimmune diseases13–15 (asthma, rheumatoid arthritis and multiple sclerosis). This evidence concerns the gene IL6 and immune system disorder.