We overexpressed Skp2 WT, S256A or S256D mutant into AMPK knockdown cells and found that expressing Skp2 and Skp2 S256D, but not Skp2 S256A, rescued cancer cell survival under hypoxia or glucose deprivation (Fig. 5c, d and Supplementary Fig. 6b). Here, SKP2 is linked to cancer.