To test this hypothesis, we implanted a highly epileptogenic patient-derived glioma xenoline (GBM22)4 that avidly releases Glu via SXC into the cortex of scid mice and evaluated the PTC for evidence of neuronal loss using pan-specific neuronal marker, NeuN and two specific markers for FSNs—PV and Wisteria Floribunda Agglutinin (WFA). Here, RBFOX3 is linked to glioma.