COL4A1 and Nephropathy: The COL4A1 p.G1239R variant was first reported as a paternally inherited mutation in a child with intracranial hemorrhage identified on prenatal screening and subsequent left porencephaly and progressive hemolytic anemia.23 The father had features of hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) syndrome.