COL4A1/2 mutations in the fetus induce susceptibility to intrauterine environment stressors that increase the risk of intraventricular hemorrhage.7 Since COL4A1/COL4A2 are among the maternal susceptibility genes for preeclampsia,43 we hypothesized that a mutation expressed in the maternal uterus may further increase the risk of prenatal brain complications and, consequently, the severity of disease. This evidence concerns the gene COL4A1 and preeclampsia.