In male HCC patients, high mRNA expressions of GINS1 (HR = 1.9, P=0.0048), GINS2 (HR = 1.93, P=0.0038), GINS3 (HR = 2.2, P=0.00064), and GINS4 (HR = 1.69, P=0.021) were significantly associated with poor OS (Figure 3A–D and Table 2). Here, GINS2 is linked to hepatocellular carcinoma.