The results showed that high mRNA expressions of GINS1 (HR = 1.81, P=0.00078), GINS2 (HR = 1.59, P=0.009), GINS3 (HR = 1.62, P=0.0064), and GINS4 (HR = 1.42, P=0.048) were significantly associated with poor overall survival (OS) in all HCC patients (Figure 2A–D). The gene discussed is GINS4; the disease is hepatocellular carcinoma.