CD4 and rheumatoid arthritis: In contrast, when compared with those of control subjects, SEB-reactive CD4 T cells of patients with RA showed lower percentages of cells expressing all three cytokines (p = 0.0004) or IFN-γ alone (p = 0.005) or in combination with IL-2 (p = 0.006) (Fig. 2a, lower panel).