Wang et al. reported that hypomethylation of CpGs in 6p21.3, where HLA-DOA is located, was associated with increased CD8 T cell tumour infiltration in serous ovarian cancer [26] whereas Ningappa et al. and Sindhi et al. demonstrated that HLA-DOA inhibits B cell presentation of antigen and consequently these authors proposed a potentially novel antirejection drug target [27, 28]. This evidence concerns the gene CD8A and ovarian serous adenocarcinoma.