Although the stroked tissue did not display the full neuropathological feature associated with chronic TDP-43 proteinopathies, i.e., the presence of highly phosphorylated TDP-43 aggregates and complete depletion of nuclear TDP-43, we showed that ischemic injury may cause a long-lasting cytoplasmic accumulation of TDP-43. The gene discussed is TARDBP; the disease is proteostasis deficiencies.