Multivariate analysis showed that tumor size (HR 5.533, 95% CI 1.251–39.287, p = 0.023), Ki-67 (HR 2.606, 95% CI 1.028–6.780, p = 0.044), pathological response (HR 4.355, 95% CI 1.438–16.871, p = 0.008), and metastatic site (HR 2.496, 95% CI 1.007–6.126, p = 0.048) had strong prognostic significance for PRS (Table 4). Here, MKI67 is linked to neoplasm.