Assuming that ENHO, RXRA, and LXRA SNPs may be involved in dyslipidaemia, related comorbidities or the mortality of HD patients, we planned the genotyping of ENHO rs2281997 and rs72735260, RXRA rs749759, rs10776909 and rs10881578, and LXRA rs2279238, rs7120118 and rs11039155 SNPs and determined the circulating adropin concentration in HD patients to show their relevance in the lipid-related pathology of ESRD requiring dialysis treatment. This evidence concerns the gene RXRA and inherited lipid metabolism disorder.