Therefore, also in HD patients, ENHO, RXRA, and LXRA single-nucleotide polymorphisms (SNPs) might be connected directly or indirectly with dyslipidaemia, comorbidities that frequently occur together with lipid abnormalities (coronary artery disease - CAD, myocardial infarction, end-stage diabetic nephropathy), and even survival probability. The gene discussed is ENHO; the disease is diabetic kidney disease.