In the present study, treatment with 20 mg/kg MPTP produced PD signs in SH-SY5Y cell and mouse models, as indicated by significantly upregulated levels of inflammatory cytokines, such as TNF-α, IL-6, iNOS, COX-2, Mac-1, and p-IκB-α (p < 0.05). The gene discussed is PTGS2; the disease is Parkinson disease.