In addition, there are certain other checkpoint molecules in the tumour microenvironment, which negatively regulate T-cells’ functionality and are worth mentioning here, including cytotoxic T lymphocyte-associated protein-4 (CTLA-4), lymphocyte activating gene 3 (Lag3), mucin domain containing-3 (Tim-3), T-cell immunoglobulin and T-cell immunoreceptor with Ig. This evidence concerns the gene HAVCR2 and neoplasm.