HPSE and melanoma: N-acetylated, N-desulfated heparin, as well as N-resulfated N- and O-desulfated heparin, significantly reduced lung colonization abilities of the highly metastatic B16-BL6 mouse melanoma, and similar effects were described with the O-sulfated, N-desulfated, N-acetyl, or N-hexanoyl heparin derivatives, all endowed with potent heparanase inhibitory activity [134,135,136].