According to the potent heparanase inhibitory activity, roneparstat was shown to efficiently attenuate the lung metastatic colonization of B16-BL6 mouse melanoma cells, which produce both P-selectin ligands and heparanase, whereas it was ineffective on dissemination from the mouse colon carcinoma MC-38 metastatic model which primarily expresses selectin ligands [164]. Here, HPSE is linked to melanoma.