EGF and neoplasm: HS-binding growth factors regulate multiple carcinogenesis processes being either mitogenic or pro-angiogenic (e.g., platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF)) and promoting tumor cell survival, invasiveness, and metastasis (e.g., hepatocyte growth factor (HGF), epidermal growth factor (EGF), and insulin-like growth factor (IGF)) [10].