RYR2 and catecholaminergic polymorphic ventricular tachycardia: The RyR2-D3638A mutation leads to 3D conformational defects, aberrant functional properties associated to RyR2 post-translational macromolecular complex remodeling for the first time revealed using CPVT patient-specific hiPSC-derived cardiomyocytes which may explain the CPVT proband’s resistance to metoprolol.