Low oxygen levels inside the tumor, or sometimes also lactic acid synthesized as by-product of anaerobic glycolysis of tumor cells, stimulate expression of hypoxia-inducible factor 1α (HIF1A) transcription factor, which induce vascular endothelial growth factor (VEGFA) production, which in turn gives rise to tumor-derived angiogenesis [1,2]. This evidence concerns the gene HIF1A and neoplasm.