Plotting of the log2 fold changes of these shared genes revealed high expression of several genes implicated in human lung cancer including the Notch inhibitor Dlk1 [38],the matrix metalloprotease Mmp12 [47] as well as the EGFR ligands Ereg and Areg which were the two most highly expressed genes in both models (Fig 2C). The gene discussed is MMP12; the disease is lung cancer.