Integration of the human miRNA-mRNA datasets with multiMiR (S6 Table) followed by mining of the ONGene [50] and TSG2.0 [51] databases identified 6 ‘validated’ interaction pairs common between IGFIR-driven tumors and human ADC involving miR-21-5p (RECK, TIMP3, TGFBR3), miR-31-5p (LATS2) and miR-150-5p (TNS4) (Fig 5D). This evidence concerns the gene TIMP3 and AIDS dementia complex.