RET and lung cancer: Genes upregulated in both IGFIR-driven tumors and human ADC included those with reported roles in lung cancer such as AURKA, SOX4, RET, MET and ETV4 while those downregulated in both species included KLF4, TIMP3, CAV1 and LATS2. Of note, a subset of these SPC-IGFIR and human lung ADC shared genes were unique to the SPC-IGFIR model when compared to tumors from C/L858R mice with the transcriptional regulator DLX5 and the secreted Wnt antagonist SFRP5 displaying the greatest positive and negative fold changes respectively (S4 Fig).