This led to the identification of 30 miRNA-mRNA interaction pairs (Fig 4C) involving known tumor suppressor targets of miR-21a-5p (Reck, Timp3 and Tgbr3) and miR-31-5p (Lats2 and Dmd) as well as oncogenic targets of miR-143-3p (Kras), miR-145-5p (Klf5, Kras) and miR-1195-5p (Met). This evidence concerns the gene TIMP3 and neoplasm.