CD40LG and infection: In the current study, we found that FcƳR2A receptor expression on platelets was decreased in severe dengue as well as in active viremia states (NS1 positive and IgM negative).Watanabe S et al have demonstrated the presence of enhancing antibodies in severe dengue which overcome the neutralizing antibodies and accelerate ADE leading to increased infection of FcƳR2A expressing platelet cells.[23] Both NS1 positive, as well as IGM negative states, are characterized by the presence of DENV in circulation.