In our meta-analysis, the decrease of CRP was also observed in obese participants and adults, that was consistent with previous findings.[42,56] Obesity was associated with increased inflammation and oxidative stress,[57] and whole grain products had been confirmed to have a strong tight with weight loss in adults,[58] so it was possible that whole grain also led to decreased inflammation simultaneously, but this study could not conclude the inverse association in healthy adults owing to the limited trials. The gene discussed is CRP; the disease is obesity disorder.