CRP and obesity due to melanocortin 4 receptor deficiency: In our meta-analysis, the decrease of CRP was also observed in obese participants and adults, that was consistent with previous findings.[42,56] Obesity was associated with increased inflammation and oxidative stress,[57] and whole grain products had been confirmed to have a strong tight with weight loss in adults,[58] so it was possible that whole grain also led to decreased inflammation simultaneously, but this study could not conclude the inverse association in healthy adults owing to the limited trials.