A previous meta-analysis for the association between TNF polymorphisms and JIA has been published, which showed no significant relationship between either TNF-α 308A/G or TNF-α 238A/G polymorphisms and JIA in European population.[16] However, the sample size of that meta-analysis was not large enough (7 studies for TNF-α 238A/G and 9 studies for TNF-α 308A/G), and they included an article that did not fit the inclusion criteria for the diagnosis of JIA. Here, TNF is linked to juvenile idiopathic arthritis.