CRP and hypertensive disorder: TNF-α stimulates vascular endothelial cells to express adhesion molecules, facilitating its adherence to leukocytes, and stimulates monocytes macrophages and other cells to secrete chemokines, causing accumulation of leukocytes at sites of inflammation.[21,22] Studies have reported significantly increasing serum C-reactive protein (CRP) in patients with hypertension, and the level of high-sensitivity C-reactive protein increases with the prolonged course of hypertension.[23,24]