Importantly, the positive correlation between SPI1 and the expression of HAVCR2 as well as that of SPI1 target genes such as ITGAX and LMO2 can be found in human T-ALL datasets (Liu et al., 2017; Van Vlierberghe et al., 2011)(Figure 5), suggesting that the regulation of HAVCR2 expression by SPI1 could play an important role in human T-ALLs. Here, SPI1 is linked to acute lymphoblastic leukemia.