SPI1 and acute lymphoblastic leukemia: The overexpression of Spi1 in T-ALL blast cells significantly increases the expression of Havcr2 and other known SPI1 target genes, such as Itgax and Lmo2 (Champhekar et al., 2015; Turkistany and DeKoter, 2011; Yashiro et al., 2017), but downregulates Myc mRNA and protein levels (Figure 4G–H).