PTEN and acute lymphoblastic leukemia: PTEN and the PI3K/AKT/mTOR pathway controlled by PTEN are critical for the etiology of human T-ALL (Gutierrez et al., 2009; Larson Gedman et al., 2009; Liu et al., 2017; Maser et al., 2007; Palomero et al., 2007), and our study may illuminate the understanding and treatment of T-ALLs associated with PTEN loss or PI3K activation.