The yellow module contains 220 genes that are preferentially expressed in the LSC-enriched subpopulation (LSChigh-Blast0); (B) Gene Ontology (GO) analysis of LSC-enriched genes in the yellow module; (C) Havcr2 and Itgax are specifically expressed in LSC-enriched (red) but not in leukemic blast (blue) subpopulations isolated from the indicated hematopoietic organs of M1-M4 Pten-null T-ALL mice; (D) Upper panel: FACS plots are overlaid to show the differential expression of HAVCR2 and ITGAX in the LSC and blast subpopulations. The gene discussed is PTEN; the disease is acute lymphoblastic leukemia.