It has been reported that the epidermal growth factor receptor (EGFR) mutation status could have an influence on the central nervous system (CNS) progression of NSCLC.9, 39, 60, 69, 71, 72 The study by Li et al analyzed 110 patients with NSCLC whose EGFR status was detected in the primary tumors and brain metastases. This evidence concerns the gene EGFR and non-small cell lung carcinoma.