BECN1 and neoplasm: For example, Sirt1 deacetylates LC3 in the nucleus and subsequently induces autophagy.14 The acetylation of Beclin 1 regulated by p300 and Sirt1 inhibits autophagosome maturation and promotes tumour growth.18 In the present study, patients with chronic benzene exposure demonstrated decreased acetylation of histone H3 in BMMNCs, consistent with our previous report.16 HQ reduced the acetylation of ATG7 and LC3 by inhibiting the activity of p300.