Ang II could stimulate the production of aldosterone by enhancing sympathetic released adrenaline and adrenal cortical globular bands, aldosterone can further activate the SNS.46 Mounting evidence indicate that RAAS is actively involved in the pathogenesis of heart failure.47, 48 The interaction between SNS and RAAS in the case of heart failure is schematically presented in the Figure S2. This evidence concerns the gene AGT and heart failure.