NFKB1 and hematoma: For example, activated nuclear factor-κB (NF-κB) was seen to migrate into the nucleus at 13–48 h after ICH and at the same time, IL-1β and tumor necrosis factor (TNF) levels increased within 1 day after ICH, while downregulation of TNF-αexpression was associated with reduction in hematoma volume [27–29].