MPAs always serve as the sensitive marker of platelet activation, and activated platelet-mediated monocytes activation promotes monocyte-evoked inflammatory response by regulating nuclear factor kappa B (NF-κB) pathway and the release of several inflammatory cytokines such as monocyte chemoattractant protein 1 (MCP-1) by TLR4 signal pathway in cardiovascular disease [12, 13]. The gene discussed is TLR4; the disease is cardiovascular disorder.