Although other signaling pathways could be activated by TGF‐β in glioma cells 15, and autocrine TGF‐β signaling maintains tumorigenicity of glioma‐initiating cells through Sry‐related HMG‐box factors 16 this is the first study showing the roles and related mechanisms of the TGF‐β–UCA1–Slug axis in the stemness and EMT of glioma cells. This evidence concerns the gene UCA1 and central nervous system cancer.