Previous studies have shown that lncRNA UCA1 contributes to drug resistance in tumors 17, 18; combining this with our results that UCA1 promotes the stemness of glioma cells, we speculate that lncRNA UCA1 could result in drug resistance in glioma cells via regulating the stemness of cells, which should be explored in future work. The gene discussed is UCA1; the disease is central nervous system cancer.