Therefore, our results are in agreement with previous studies demonstrating that rapamycin-dependent stimulation of autophagy is likely one of the principal mechanisms by which the reduction of toxic protein aggregates, comprised of Aβ, aberrantly expressed APP and APP metabolites, is achieved in the brains of Tg-AD mice [18, 19, 23, 26, 31, 40, 79, 95]. This evidence concerns the gene APP and Alzheimer disease.