CRTC1 and neoplasm: We evaluated mTOR signaling by immunohistochemical analysis of phosphorylated S6 kinase (pS6K; reflecting target of rapamycin complex 1 [TORC1] signaling) and phosphorylated AKT (pAKT; reflecting TORC2 signaling) using archived tumor biopsy samples at the time of diagnosis (baseline).