ACTA1 and renal fibrosis: HIV-derived lentiviral vectors designed for expression of type II TGF-β receptor (TBRII) were reported to attenuate renal fibrosis better, as estimated by expression levels of extracellular matrix synthesis, such as fibronectin and collagen III, and expression of α-SMA in both cultured renal epithelial cells and renal fibroblasts compared with non-lentiviral constructs [61].